Andrew P Lieberman Selected Research

X-Linked Bulbo-Spinal Atrophy

1/2021	Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.
1/2020	MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.
1/2018	Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction.
12/2016	Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.
11/2016	Polyglutamine androgen receptor-mediated neuromuscular disease.
1/2016	Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet.
1/2016	Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing.
2/2015	Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.
1/2015	Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
11/2014	A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases.

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Andrew P Lieberman Research Topics

Disease

32	X-Linked Bulbo-Spinal Atrophy 01/2021 - 08/2002
19	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 01/2006
14	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 12/2021 - 09/2007
8	Alzheimer Disease (Alzheimer's Disease) 09/2019 - 11/2014
7	Neoplasms (Cancer) 01/2018 - 04/2004
6	Muscular Atrophy (Muscle Atrophy) 01/2020 - 05/2004
5	Huntington Disease (Huntington's Disease) 01/2021 - 11/2014
5	Atrophy 01/2020 - 11/2007
4	Neuromuscular Diseases (Neuromuscular Disease) 03/2019 - 01/2016
4	Parkinson Disease (Parkinson's Disease) 01/2019 - 08/2012
4	Ataxia (Dyssynergia) 10/2016 - 06/2007
3	Lysosomal Storage Diseases (Lysosomal Storage Disease) 12/2021 - 03/2012
3	Disease Progression 01/2017 - 11/2012
3	Cognitive Dysfunction 10/2016 - 06/2007
3	Dementia (Dementias) 11/2015 - 11/2010
3	Frontotemporal Dementia (Semantic Dementia) 08/2012 - 02/2010
2	Niemann-Pick Diseases (Niemann Pick Disease) 11/2019 - 06/2019
2	Brain Neoplasms (Brain Tumor) 01/2018 - 10/2017
2	Proteostasis Deficiencies 11/2014 - 02/2010
2	Muscle Weakness 05/2014 - 11/2007
2	Androgen-Insensitivity Syndrome (Testicular Feminization) 01/2011 - 01/2006
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 03/2010 - 02/2010
2	Tauopathies 05/2009 - 03/2009
2	Sphingolipidoses (Sphingolipidosis) 09/2007 - 06/2007
1	TDP-43 Proteinopathies 12/2021
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 11/2020
1	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 11/2020
1	Body Weight (Weight, Body) 11/2019
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2019
1	Infarction (Infarctions) 01/2019
1	Late Onset Disorders 01/2018
1	Hypertrophy 01/2017
1	Acquired Immunodeficiency Syndrome (AIDS) 10/2015
1	Myeloid Sarcoma (Chloroma) 09/2015
1	Weight Loss (Weight Reduction) 05/2015
1	Animal Disease Models 01/2015
1	Glioma (Gliomas) 07/2014
1	Neuroinflammatory Diseases 01/2014
1	Inflammation (Inflammations) 01/2014
1	Chromosomal Instability (Chromosome Stability) 10/2012
1	Genomic Instability 10/2012

Drug/Important Bio-Agent (IBA)

30	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 08/2002
27	polyglutamineIBA 01/2021 - 08/2002
21	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2004
20	LipidsIBA 01/2021 - 06/2007
12	Glutamine (L-Glutamine)FDA Link 01/2017 - 02/2004
7	CholesterolIBA 12/2021 - 06/2007
6	AndrogensIBA 03/2019 - 10/2006
4	SphingolipidsIBA 05/2015 - 06/2007
3	DNA-Binding Proteins (DNA Binding Protein)IBA 12/2021 - 02/2010
3	Mutant Proteins (Protein, Mutant)IBA 03/2020 - 01/2006
3	Carrier Proteins (Binding Protein)IBA 01/2019 - 03/2009
2	Pharmaceutical PreparationsIBA 06/2019 - 10/2017
2	Amyloid (Amyloid Fibrils)IBA 01/2019 - 11/2015
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 10/2012
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2015 - 11/2014
2	Apolipoproteins E (ApoE)IBA 11/2014 - 11/2012
2	Flutamide (Eulexin)FDA LinkGeneric 07/2014 - 01/2011
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2012 - 08/2012
2	Staphylococcal Protein A (Protein A)IBA 10/2012 - 06/2005
2	ProgranulinsIBA 03/2010 - 02/2010
2	Beclin-1IBA 09/2007 - 06/2007
1	Lysergic Acid Diethylamide (LSD)IBA 12/2021
1	Deubiquitinating EnzymesIBA 01/2021
1	Prion ProteinsIBA 11/2020
1	MEF2 Transcription FactorsIBA 01/2020
1	Ligases (Synthetase)IBA 01/2020
1	UbiquitinIBA 01/2020
1	BilirubinIBA 11/2019
1	HDL LipoproteinsIBA 11/2019
1	alpha-SynucleinIBA 01/2019
1	Oxytocin Receptors (Oxytocin Receptor)IBA 01/2019
1	AntioxidantsIBA 01/2019
1	Glycoproteins (Glycoprotein)IBA 10/2018
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2018
1	ClenbuterolIBA 01/2017
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 12/2016
1	Peptides (Polypeptides)IBA 12/2016
1	HSP27 Heat-Shock ProteinsIBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 11/2015
1	Dopamine (Intropin)FDA LinkGeneric 11/2015
1	Threonine (L-Threonine)FDA Link 02/2015
1	Alanine (L-Alanine)FDA Link 02/2015
1	SynucleinsIBA 01/2015
1	Androgen Antagonists (Antiandrogens)IBA 07/2014
1	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 07/2014
1	Interleukin-3 (Interleukin 3)IBA 01/2014
1	Interleukin-10 (Interleukin 10)IBA 01/2014
1	Interleukin-13IBA 01/2014
1	miglustat (Zavesca)FDA Link 01/2014
1	ApolipoproteinsIBA 11/2012
1	Nuclear Proteins (Protein, Nuclear)IBA 10/2012

Therapy/Procedure

4	Therapeutics 01/2018 - 11/2014
2	Precision Medicine 01/2018 - 10/2017
1	Cell Transplantation 01/2021
1	Surgical Decompression 09/2015
1	Radiotherapy 09/2015
1	Injections 07/2014